Peter j russell igenetics free download pdf article has multiple issues. Unsourced material may be challenged and removed.
Out of date, rightly flagged since 2008, needs references. More specifically, a morphogen is a signaling molecule that acts directly on cells to produce specific cellular responses depending on its local concentration. Typically, morphogens are produced by source cells and diffuse through surrounding tissues in an embryo during early development, such that concentration gradients are set up. In contrast, cells close to the source of morphogen will receive high levels of morphogen and will express both low- and high-threshold target genes. Distinct cell types emerge as a consequence of the different combination of target gene expression. In this way, the field of cells is subdivided into different types according to their position relative to the source of the morphogen. A morphogen spreads from a localized source and forms a concentration gradient across a developing tissue.
Drosophila embryo is more complex than the simple gradient model would indicate. Exposure of embryos to exogenous retinoids especially in the first trimester results in birth defects. I receptors causing the latter to be transphosphorylated. Essentially the embryo remains a single cell with over 8000 nuclei evenly spaced near the membrane until the fourteenth cell division, when independent membranes furrow between the nuclei, separating them into independent cells. The nuclear targets of signal transduction pathways are usually transcription factors, whose activity is regulated in a manner that reflects the level of morphogen received at the cell surface. Discrete target genes respond to different thresholds of morphogen activity. Low-threshold’ target genes require only low levels of morphogen activity to be regulated and feature enhancers that contain many high-affinity binding sites for the transcription factor.